Stability and liquid-liquid phase separation in mixed saturated lipid bilayers.

The phase stability of a fluid lipid bilayer composed of a mixture of DC(18)PC, (DSPC), and a shorter DCn(s) PC, with n(s) from 8 to 17, has been studied using a self-consistent field theory that explicitly includes molecular details and configurational properties of the lipid molecules. Phase separation between two liquid phases was found when there was a sufficient mismatch between the hydrophobic thicknesses of the two bilayers composed entirely of one component or the other. This occurs when n(s) 12, we observe that the effect of the shorter lipid is to increase the susceptibility of the system to fluctuations in the concentration. This is of interest, given that a common motif for the anchoring of proteins to the plasma membrane is via a myristoyl chain, that is, one with 14 carbons.